Group Members AG Mindt 2022
Bioinorganic Radiochemistry
Prof. Dr. Thomas L. Mindt
18.04. – 21.04.2024
The European Symposium on Radiopharmacy and Radiochemistry (ESRR) took place this year in beautiful Coimbra, Portugal. Tom, who is deputy president of the board and member of the scientific committee of the ESRR, gave a presentation on “Synthesis and Preclinical Evaluation of BOLD-100 Radiolabeled with Ruthenium-97/103”. With more than 300 attendees from allover the world, we had a new record. The congress has been steadily growing during the past years, which is quite a success story.
15.04.2024
Today, Dr. Sandra Koziel from the University of Wroclaw, Poland, will start her 3-month tenure in the AG Mindt as a visiting scientist. Hearty welcome to Sandra and good luck with your research project!
27.3.2024
Today, Philipp Salomon defended successfully his MSc thesis on the topic … top secret because of industry collaborations 🙂. Hearty congratulations and thank you Philipp for your important contributions that brought the project a big step forward. We wish you all the best for your future!
13.3.-15.03.2024
This year´s retreat of the doctorate school of chemistry of the faculty of chemistry (DoSChem) of the University of Vienna (panel C) took place at the marvelous Szidonia Castle in Hungria near the border to Austria. Excellent presentations of external speakers as well as of PhD candidates. This event gives PhD students as well as PI´s the opportunity for exchanges. The photo below shows only participants of the Inorganic Chemistry “gang”. All made possible by the DoSChem – thank you!
14.3.2024
Read up on the latest news about triazolo-peptidomimetics in Xabier Guarrochena´s just published article “Amide-to-triazole switch in somatostatin-14-based radioligands: Impact on receptor affinity and in vivo stability” in Pharmaceutics (https://doi.org/10.3390/pharmaceutics16030392). The amide-to-triazole switch methodology was applied for the first time to a cyclic peptide, the somatostatin analogue AT2S, leading to the identification of a novel pansomatostatin ligand [111In]In-XG1 with improved properties. This work was realized in a collaboration with Greek colleagues at Demokritos, Athens. Congratulations to all authors!
12.3.2024
As a sequel of publications using radioisotopes of ruthenium in radiopharmaceutical/chemical research, Barbara Happl´s second paper on “Synthesis and preclinical evaluation of BOLD-100 radiolabeled with ruthenium-97 and ruthenium-103” just came out in Dalton Transactions (DOI: 10.1039/d4dt00118d). Optimizing the applied dose of radiolabeled BOLD-100 paves the way to imaging studies with [97Ru]BOLD-100. This was an international, multi-center study together with colleagues of the Medical University Vienna, TU Wien, Institut Laue-Langevin (ILL, Grenoble, FR), GIP Arronax (Nantes, FR) and the Nantes Université (FR). Congratulations to all authors!
22.2.2024
Today, we celebrated the farewell of Dr. Marie R. Brandt at the (infamous) Milano Restaurant near the Chemistry Department, who decided to leave the UniVie for new opportunities. Marie, I am / we are very thankful for all of your great work and support over the years and we wish you all the very best for future endeavours! I am looking forward to stay in touch and you are always a very welcomed guest at the AG Mindt.
13.2.2024
Tom gave an invited talk at the prestiguous Gordon Reasearch Conference on the Chemistry and Biology of Peptides in Ventura Beach, California, USA. His talk was well received and discussions for new collaborations with American colleagues were initiated. A really nice and interesting conference! To be continued…
19.01.2024
Niko and Tom travelled to Paris for a meeting with collaboration partners of the Gasser group at Chemie ParisTech. It was a fruitful in person meeting with vivid exchange of ideas on the project jointly funded by the French ANR and Austrian FWF. At the same occasion, Tom delivered an invited lecture on “Radioactive Labeled Molecules for the Diagnosis and Therapy of Cancer” and Niko worked out experimental details with Ruonan on Photo Dynamic Therapy (PDT) in vitro experiments (see also 26.08.23).
18.12.2023
Our newest publication on the improved synthesis of the 89Zr-chelator DFO* just got accepted in ChemMedChem (https://doi.org/10.1002/cmdc.202300495). Changing the protective group strategy led to a significant improvement, which will make DFO* more readily available to the community interested in 89Zr-PET imaging, e.g., immunoPET applications. Congratulations to all authors!
6.12.2023
Today, Marlene Gryllmaier defended successfully her MSc thesis on the topic … top secret because of industry collaborations 🙂. Hearty congratulations Marlene and thank you for your excellent work that brought us an important step forward in the project. All the very best for the future!
21.11.2023
Marie Brandt´s publication on “Quality Assurance Investigations and Impurity Characterization During Upscaling of [177Lu]Lu-PSMAI&T” just came out in Molecules (https://doi.org/10.3390/molecules28237696). Read up on the challenges that can come with the establishment of the routine production of radiopharmaceuticals in the clinic. This was a collaboration with colleagues of the Medical University of Vienna. Congratulations to all authors!
15.11.2023
Barbara Happl´s first paper just came out in Pharmaceutics (DOI: https://doi.org/10.3390/pharmaceutics15112626). Read up on the first report on a radiolabelled analogue of the anticancer drug BOLD-100, which is currently in clinical trials. The publication opens a series of future papers from our group reporting the use of ruthenium radioisotopes. The project was realized together with colleagues in Switzerland at the Paul Scherrer Institute. Congratulations to all authors!
14.10.2023
To celebrate the opening of our new hotlabs and wetlabs at the University campus UZA II, we invited our new neighbours for a BBQ on one of the last warm and sunny days of the year before fall starts. Great event with hotdogs & pumpkins and cold beverage. Nice to meet and chat with our new colleagues at the UZA II and get to know them a bit better.
02.10.2023
Today starts our new colleague Julia Friesenbichler. She will support us in all biological work, especially cell culture and cell experiments by bringing in her expertise in medical and pharmaceutical biotechnology. Welcome Julia to our group and we wish you all a good start!
26.08.2023
Our newest review on “Theranostics with photodynamic therapy for personalized medicine: to see and to treat” has just been accepted for publication in the high impact factor journal Theranostics. Read up on the background of Niko´s (AG Mindt, UniVie) and Youchao´s (AG Gasser, Chimie ParisTech, Paris, France) project funded by the Austrian FWF (I 5721-N) and the French ANR (AAPG2021).
Congrats to the authors – what took long, finally ends well 😀.
14.08.2023
Today, Robin Maradan starts his PhD studies in the AG Mindt. He will work on a FWF funded project aiming at new applications of pretargeting approaches (FWF P36706-B) in collaboration with Dr. Thomas Wanek of the Medical University of Vienna and Prof. Dr. Hannes Mikula of the Technische Universität Wien. Robin joins the AG Mindt from the University of Burgundy, France, where he was trained by Tom´s former postdoc in Switzerland, Dr. Ibai Valverde. Hearty welcome to Robin and good luck for your PhD studies in Vienna!
08.08.2023
Resulting from the successful and long-term collaboration with the Gasser group at Chimie ParisTech, check out our most recent publication on “Towards Ruthenium(II)-Rhenium(I) Binuclear Complexes as Photosensitizers for Photodynamic Therapy” (doi.org/10.1002/cbic.202300467).
07.08.2023
Exciting news: The new octadentate chelator DFO* for the stable complexation of Zirconium-89 (89Zr) invented by the groups of Mindt and Gasser (https://doi.org/10.1039/C4CC05558F), which has been shown by Danielle Vugts and coworkers in Amsterdam to be superior to the current 89Zr standard chelator DFO (https://doi.org/10.1007/s00259-016-3499-x), has now entered the clinic. Led by PI C.W. Menke-van der Houven van Oordt, MD, PhD, of the Amsterdam UMC, 89Zr-DFO*-trastuzumab is investigated for the first time in patients as immunoPET agent for the diagnosis of HER2-positive breast or gastric cancer (https://ichgcp.net/clinical-trials-registry/NCT05955833). First results of the clinical study are eagerly awaited.
30.06.2023
After the 7-year funding period of the Ludwig Boltzmann Society (https://lbg.ac.at/), our institute LBIAD (Ludwig Boltzmann Institute Applied Diagnostics) comes to an end. The LBIAD was a successful project that connected people from different research fields of the University of Vienna and the Medical University Vienna ranging form basic science to clinical applications. As the former head of the program line Imaging Biomarker, I am grateful for having been given the opportunity to be part of the LBIAD team.
With the newly founded Joint Applied Medicinal Radiochemistry Facility of the University of Vienna and the Medical University of Vienna, the established scientific network and collaborations of researchers in radiopharmacy/chemistry, pathology, pharmacology, health economics and nuclear medicinal will continue.
29.06.2023
Today, the farewell of Veronika Felber and Anna Stingeder took place at the pub Highlander. Good food and cold drinks 😀.
Thank you Vroni and Anna for your important contributions to the working group AG Mindt. We wish you all the very best and success in future! Of course, we will stay in touch.
22.-26.05.2023
The most important congress in the field of radiochemical/pharmaceutical sciences, the International Symposium on Radiopharmaceutical Sciences (iSRS), took place this year in Honolulu, Hawaii (USA).
Irene Feiner and Julia Kronberger represented the AG Mindt on the tropical island and gave each a poster presentation.
30.03.2023
Our annual AG Mindt field trip brought us to the the famous Viennese museum of fine arts where we participated in a Mystery Hunt! The objective was to find exihibts following carfully drafted and arty little cards containing clues and hints. Afterwards we enjoyed a real Swiss fondue (and raclette) at the Swiss restaurant Chamäleon in the 1st district. Delicious melted cheese!
30.03.2023
Today, Raphael Posch defended his Master thesis entitled Synthesis & evaluation of modified RM2 radiopeptides for the delivery of [111In]Indium to diseased tissue.
Thanks Raphi for your hard work and good luck for the future!
27.03.2023
Read up on solid phase peptide synthesis in the paper of Xabier Guarrochena and Barbara Kaudela that just came out in the Journal of Peptide Science: Automated solid-phase synthesis of metabolically stabilized triazolo-peptidomimetics – https://doi.org/10.1002/psc.3488.
Congrats Xabi and Barbara!
22.-24.03.2023
This week, we went for another annual retreat of the Panel C of the Doctorate School in Chemistry of the University of Vienna. In famous Fürstenfeld, we enjoyed 3 days of science as well as various in- and outdoors activities. A trip to the Zotter chocolate factory on Thursday afternoon was just sweet 😀.
14.03.2023
Tom gave an invited lecture on Theranostic Approaches in Nuclear Medicine with Metallic Radioisotopes during an educational session of the EMIM 2023 in Salzburg, Austria. It was only a short trip from Vienna to the largest EMIM ever (900+ participants).
28.02.2023
Today, Barbara Happl defended successfully her PhD thesis entitled Development of Novel Ruthenium-based Radiopharmaceuticals.
Hearty congratulations and all the very best for the future!
20.01.2023
Prof. Dr. Sebastian Schütze, Rector of the University of Vienna, visited the Institute of Inorganic Chemistry today. He also stepped by our synthesis lab (Lab1) and met the AG Mindt.
It was a short visit but a nice and rare occasion to shake hands with the rector.
- 07.12.2022
Today, our traditional annual group excursion to the Christmas market in the old AKH took place. It was very pre-Xmassy but cold – though, the Glühwein (hot spiced wine) kept us warm.
Annual Team Christmas Market Vienna Event 2022 - 1.12.2022
At the Austrian Peptide Symposium 2022 in Vienna, Tom Mindt gave an invited lecture on Metabolically stabilized triazolo-peptidomimetics for tumor targeting. Xabier Guarrochena joint the effort to spread the joy on triazolo-peptidomimetics by giving two poster presentations on related topics.
Xabi won the best poster award – congratulations!
Nice local meeting with interesting contributions from all over the world. - 24.11.-27.11.2022
This week, we travelled to Verona Italy for attending the ESRR 2022. As a member of the ESRR board, Tom Mindt was busy with meetings and serving as chairman, while Xabi Guarrochena and Julia Raitanen presented posters. Excellent congress in a nice Italian (Xmas) setting.
ESRR 2022 - 07.11.2022
Today, Carolina Giammei defended successfully her PhD thesis entitled From Single- to Dual-Radiotracer Applications in Nuclear Medicine. Afterwards, we had a nice celebration at the Stiegl Ambulance of the old AKH.
Hearty congratulations and all the best luck and success for the future!
- 01.11.2022
Marlene Grillmayrs started her MSc thesis in our group today. She will join our efforts in the development of novel applications for Auger electron emitting radiometals.
Hearty welcome and a good start Marlene! - 17.10.2022
Today, Barbara Kaudela defended successfully her MSc thesis entitled Automated Synthesis of Triazolo-Peptidomimetics.
Hearty congratulations and all the best luck and success for the future! - 04.10.2022
My Turkish friend, Dr. Ayfer Yurt Kılçar from Ege University, Izmir, Turkey (whom I met in Izmir 2021), started as a visiting scientist in the working group Bioinorganic Radiochemistry.
Hearty welcome and a good start Ayfer! Enjoy your stay in Vienna! - 22.09.-24.09.2022
We participated at the AGRR 2022, the meeting of radiochemists and radiopharmacists from German-speaking countries (DE, AT, CH). Julia Raitanen gave a nice presentation. Nice small conference with interesting contributions. Prof. W. Mier from Heidelberg demonstrated again his excellent skills as a photographer 😀
- 14.09.-18.09.2022
We attended the TeraChem 2022 conference, which takes place every 4th year in Bressanone (IT). Great talks and posters and all that exclusively about applications of radioactive metals! Great to meet again many friends and colleagues from Europe, US, and Canada. We also met Pawel Halik and his wife Patricia as well as Prof. Dr. Marianne Patt of Leipzig and had pizza for dinner together.
- 26.08.2022
Today, the second paper resulting from the successful collaboration with Prof. S. Ametamey (ETH Zurich, CH) and colleagues at the Medical University Vienna (AT) entitled Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1 was published in the European Journal of Nuclear Medicine and Molecular Imaging.
Hearty congratulations to all authors! - 05.08.2022
Nedra Jouini is the first PhD student of the working group Mindt – Bioinorganic Radiochemistry, who defended her PhD work and graduated.
Thesis title: Towards radiolabeled peptides for imaging the immune checkpoint target PD-L1.
Great job Nedra! Hearty congratulations and all the best luck and success for the future! - 01.08.2022
Today is the first day of Johannes Nikodemus Staudinger (Niko), who starts his PhD on the FWF/ANR project Bi-Metallic Complexes for Synergistic and Theranostic Applications (FWF project No. I5721) in collaboration with Prof. G. Gasser (Chimie ParisTech, FR).
Hearty welcome and a good start Niko! - 21.06.2022
For this year´s social group event, we went to test our capabilities in playing Minigolf. Just before that, we got additional power from a nice lunch at a steak house! It was a great, sunny, and (quite) hot day with lots of fun J.
- 29.05.-02.06.2022
We went to Nantes (FR) for the ISRS 2022, one of the most important international congresses in the field of radiopharmaceutical sciences. After a series of on-line congresses during the past 2 years, this was the first in person congress for many applicants. Great scientific talks and posters as well as (again) personal interactions with colleagues and friends.
- 12.05.-14.05.2022
The second PhD students´ retreat of the panel C of DoSChem (see blog entry 05.11.-08.11.2021) took place in Frankenfels, Austria. Again we enjoyed a nice event with interesting scientific contributions and social events. Having the retreats in Spring instead of previously winter was certainly a good idea!
- 08.04.2022
Read up on the recently published EANM guideline on quality risk management for radiopharmaceuticals in European Journal of Nuclear Medicine and Molecular Imaging.
This guideline is the result of Tom´s involvement in the Radiopharmacy committee of the EANM. - 07.04.2022
Nedra Jouini´s publication on Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD−L1 is now available on-line in ChemMedChem.
Congrats Nedra!
- 07.03.-31.05.2022
Xabi Guarrochena spent 3 months with our collaboration partners at Democritos, Athens (Greece). Together with Dr. T. Maina, Dr. B. Nock and their PhD student Panagiotis Kanellopoulos, he evaluated some of his triazole-peptidomimetics in vitro and in vivo.
Super collaboration with our Greek friends (thank you!) and obviously a great time for Xabi.
- 15.02.2022
Today starts Dr. Magdalena Gumiela on an industry project investigating the application of alpha particle emitting radionuclides in nuclear medicine.
Hearty welcome and a good start Magda! - 01.02.2022
Our new paper on Unexpected transformation of n.c.a. [111In]InCl3 in stock solutions into an unreactive [111In]In-species just got published in Applied Radiation and Isotopes.
Congratulations to all authors!
- 03.11.2021
This is the farewell of Volkan Tekin who will move on to a position in the labs of Prof. Suzanne Lapi at the University of Alabama at Birmingham (US).
Thank you Volkan for your great work and good luck for the future!
- 05.11.-08.11.2021
The new Doctorate School in Chemistry (DoSChem) of the University of Vienna organizes annual retreats for PhD students including scientific presentations, invited speakers, and social events. The DoSChem has 3 panels. The working group Bioinorganic Radiochemistry belongs to the largest panel C, which represents the research areas Synthesis&Catalysis and Biological&Medicinal Chemistry. The first retreat of panel C took place in Admont, Austria. A very nice event thanks to the DoSChem!
- 01.11.2021
Together with colleague Prof. Rösch in Mainz (DE) we just published the paper on Development and in vitro evaluation of new bifunctional 89Zr-chelators based on the 6-amino-1,4-diazepane scaffold for immuno-PET applications in Nuclear Medicine and Biology.
Enjoy the reading!
- 20.09.-26.09.2021
Tom Mindt received a fellowship of the Turkish funding agency TUBITAK as a visiting scientist and travelled to Izmir (TR) to give invited lectures at the Ege University (Izmir), Celal Bayar University (Manisa), and Adnan Menderes University (Aydin).
It was a great experience, both scientifically and socially and resulted in potential future collaborations as well as many new Turkish friends!
- 10.09.2021
After partial loosening of the anti Covid-10 safety regulations by the Austrian government, we enjoyed our annual social group event in the famous Viennese amusement park, the Prater. It was a great day with good food and plenty of rides on roller coasters!
- 07.09.2021
Together with colleagues of the ETH Zurich (CH), we just published a joint paper on First-in-Humans Brain PET Imaging of the GluN2B-Containing N-methyl-d-aspartate Receptor with (R)-11C-Me-NB1 in Journal of Nuclear medicine and Molecular Imaging.
Congrats to all people involved in Austria and Switzerland!
- 04.09.2021
Congrats to Irene Feiner whose review on The Race for Hydroxamate-Based Zirconium-89 Chelators just came out in the journal Cancers.
Enjoy reading this extensive overview of the field.
- 01.09.2021
Today, Barbara Kaudela starts her MSc project on the automated solid-phase synthesis of trizaolo-peptidomimetics.
Hearty welcome and a good start Barbara! - 01.06.2021
AG Mindt 2021 The whole working group met in person (outdoors) for the first time since the start of the Covid-19 pandemic.
It was really nice to meet again and it resulted in a new group picture 🙂 . - 27.05.2021
The paper of Nathalie Grob (ETH Zurich, CH) entitled Improved Tumor-Targeting with Peptidomimetic Analogs of Minigastrin 177Lu-PP-F11N got published in Cancers.
Congrats Nathalie!
- 03.05.2021
Today, Julia Kronberger starts her PhD on the FWF project Impact of the K-Ras Status on the Activity of Albumin-Targeted Anticancer Drugs (project No. P32886-B).
This is a collaboration with Prof. P. Heffeter (Medical University of Vienna) and Prof. C. Kowol (University of Vienna).
Hearty welcome and a good start Julia! - 16.04.2021
Our publication on 1,5-Disubstituted 1,2,3-Triazoles as Amide Bond Isosteres Yield Novel Tumor-Targeting Minigastrin Analogs just came out in Medicinal Chemistry Letters.
This work is the results of a collaboration with my former postdoc Dr. Ibai Valverde (Université de Bourgogne, FR) and former PhD student Dr. Nathalie Grob (ETH Zurich, CH).
- 01.04.2021
Today we welcome two new group members: Dr. Veronika Felber and Anna Stingeder.
Vroni will work on an LBIAD project that aims at novel imaging applications and Anna will support our group in any regards to biological experiments.
Hearty welcome and a good start Anna and Vroni! - 28.02.2021
Today is the last day of Dr. Lisa Recnik who worked on an FWF project investigating peptidomimetics for applications in nuclear medicine (project No. P 31477-B28).
All the best and good luck for the future Lisa! - 12.02.2021
Read up on the updated regulations for the production of radiopharmaceuticals:
Guideline Guideline on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals published in the European Journal of Nuclear Medicine and Molecular Imaging – Radiopharmacy and Chemistry.
This guideline is the result of Tom´s involvement in the Radiopharmacy committee of the EANM.
- 18.12.2020
Today starts Dr. Barbara Lugato on an industry project developing new applications for Auger electron emitting radionuclides in collaboration with French academic and industrial partners.
Hearty welcome and a good start Barbara! - 16.11.2020
Today starts Dr. Volkan Tekin on an industry project for the development novel chelators for therapeutic radiometals in collaboration with Prof. G. Gasser of the Chimie ParisTech.
Hearty welcome and a good start Volkan! - 02.11.2020
Today starts Dr. Irene Feiner on the FFG Bridge-1 project Radiostar (project No. 880630) which is a collaboration with colleagues of the Technical University of Vienna and the Austrian company DSD-Pharma.
Hearty welcome and a good start Irene! - 01.10.2020
In the midst of the Covid-19 pandemic, Tom Mindt becomes Professor in Bioinorganic Radiochemistry at the University of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry.
