mindtb66@univie.ac.at

Today, our traditional annual group excursion to the Christmas market in the old AKH took place. It was very pre-Xmassy but cold – though, the Glühwein (hot spiced wine) kept us warm.

At the Austrian Peptide Symposium 2022 in Vienna, Tom Mindt gave an invited lecture on Metabolically stabilized triazolo-peptidomimetics for tumor targeting. Xabier Guarrochena joint the effort to spread the joy on triazolo-peptidomimetics by giving two poster presentations on related topics.
Xabi won the best poster award – congratulations!
Nice local meeting with interesting contributions from all over the world.

This week, we travelled to Verona Italy for attending the ESRR 2022. As a member of the ESRR board, Tom Mindt was busy with meetings and serving as chairman, while Xabi Guarrochena and Julia Raitanen presented posters. Excellent congress in a nice Italian (Xmas) setting.

Today, Carolina Giammei defended successfully her PhD thesis entitled From Single- to Dual-Radiotracer Applications in Nuclear Medicine. Afterwards, we had a nice celebration at the Stiegl Ambulance of the old AKH. 
Hearty congratulations and all the best luck and success for the future!

Marlene Grillmayrs started her MSc thesis in our group today. She will join our efforts in the development of novel applications for Auger electron emitting radiometals.
Hearty welcome and a good start Marlene!

Today, Barbara Kaudela defended successfully her MSc thesis entitled Automated Synthesis of Triazolo-Peptidomimetics.
Hearty congratulations and all the best luck and success for the future!

My Turkish friend, Dr. Ayfer Yurt Kılçar from Ege University, Izmir, Turkey (whom I met in Izmir 2021), started as a visiting scientist in the working group Bioinorganic Radiochemistry.
Hearty welcome and a good start Ayfer! Enjoy your stay in Vienna!

We participated at the AGRR 2022, the meeting of radiochemists and radiopharmacists from German-speaking countries (DE, AT, CH). Julia Raitanen gave a nice presentation. Nice small conference with interesting contributions. Prof. W. Mier from Heidelberg demonstrated again his excellent skills as a photographer 😀

We attended the TeraChem 2022 conference, which takes place every 4^th year in Bressanone (IT). Great talks and posters and all that exclusively about applications of radioactive metals! Great to meet again many friends and colleagues from Europe, US, and Canada. We also met Pawel Halik and his wife Patricia as well as Prof. Dr. Marianne Patt of Leipzig and had pizza for dinner together.

Today, the second paper resulting from the successful collaboration with Prof. S. Ametamey (ETH Zurich, CH) and colleagues at the Medical University Vienna (AT) entitled Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[¹¹C]Me-NB1 was published in the European Journal of Nuclear Medicine and Molecular Imaging.
Hearty congratulations to all authors!

Nedra Jouini is the first PhD student of the working group Mindt – Bioinorganic Radiochemistry, who defended her PhD work and graduated.
Thesis title: Towards radiolabeled peptides for imaging the immune checkpoint target PD-L1.
Great job Nedra! Hearty congratulations and all the best luck and success for the future!

Today is the first day of Johannes Nikodemus Staudinger (Niko), who starts his PhD on the FWF/ANR project Bi-Metallic Complexes for Synergistic and Theranostic Applications (FWF project No. I5721) in collaboration with Prof. G. Gasser (Chimie ParisTech, FR).
Hearty welcome and a good start Niko!

For this year´s social group event, we went to test our capabilities in playing Minigolf. Just before that, we got additional power from a nice lunch at a steak house! It was a great, sunny, and (quite) hot day with lots of fun J.

We went to Nantes (FR) for the ISRS 2022, one of the most important international congresses in the field of radiopharmaceutical sciences. After a series of on-line congresses during the past 2 years, this was the first in person congress for many applicants. Great scientific talks and posters as well as (again) personal interactions with colleagues and friends.

The second PhD students´ retreat of the panel C of DoSChem (see blog entry 05.11.-08.11.2021) took place in Frankenfels, Austria. Again we enjoyed a nice event with interesting scientific contributions and social events. Having the retreats in Spring instead of previously winter was certainly a good idea!

Read up on the recently published EANM guideline on quality risk management for radiopharmaceuticals in European Journal of Nuclear Medicine and Molecular Imaging.
This guideline is the result of Tom´s involvement in the Radiopharmacy committee of the EANM.

Nedra Jouini´s publication on Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD−L1 is now available on-line in ChemMedChem.
Congrats Nedra!

Xabi Guarrochena spent 3 months with our collaboration partners at Democritos, Athens (Greece). Together with Dr. T. Maina, Dr. B. Nock and their PhD student Panagiotis Kanellopoulos, he evaluated some of his triazole-peptidomimetics in vitro and in vivo.
Super collaboration with our Greek friends (thank you!) and obviously a great time for Xabi.

Today starts Dr. Magdalena Gumiela on an industry project investigating the application of alpha particle emitting radionuclides in nuclear medicine.
Hearty welcome and a good start Magda!

Our new paper on Unexpected transformation of n.c.a. [¹¹¹In]InCl₃ in stock solutions into an unreactive [¹¹¹In]In-species just got published in Applied Radiation and Isotopes.
Congratulations to all authors!

This is the farewell of Volkan Tekin who will move on to a position in the labs of Prof. Suzanne Lapi at the University of Alabama at Birmingham (US).
Thank you Volkan for your great work and good luck for the future!

The new Doctorate School in Chemistry (DoSChem) of the University of Vienna organizes annual retreats for PhD students including scientific presentations, invited speakers, and social events. The DoSChem has 3 panels. The working group Bioinorganic Radiochemistry belongs to the largest panel C, which represents the research areas Synthesis&Catalysis and Biological&Medicinal Chemistry. The first retreat of panel C took place in Admont, Austria. A very nice event thanks to the DoSChem!

Together with colleague Prof. Rösch in Mainz (DE) we just published the paper on Development and in vitro evaluation of new bifunctional ⁸⁹Zr-chelators based on the 6-amino-1,4-diazepane scaffold for immuno-PET applications in Nuclear Medicine and Biology.
Enjoy the reading!

Tom Mindt received a fellowship of the Turkish funding agency TUBITAK as a visiting scientist and travelled to Izmir (TR) to give invited lectures at the Ege University (Izmir), Celal Bayar University (Manisa), and Adnan Menderes University (Aydin).
It was a great experience, both scientifically and socially and resulted in potential future collaborations as well as many new Turkish friends!

After partial loosening of the anti Covid-10 safety regulations by the Austrian government, we enjoyed our annual social group event in the famous Viennese amusement park, the Prater. It was a great day with good food and plenty of rides on roller coasters!

Together with colleagues of the ETH Zurich (CH), we just published a joint paper on First-in-Humans Brain PET Imaging of the GluN2B-Containing N-methyl-d-aspartate Receptor with (R)-¹¹C-Me-NB₁ in Journal of Nuclear medicine and Molecular Imaging.
Congrats to all people involved in Austria and Switzerland!

Congrats to Irene Feiner whose review on The Race for Hydroxamate-Based Zirconium-89 Chelators just came out in the journal Cancers.
Enjoy reading this extensive overview of the field.

Today, Barbara Kaudela starts her MSc project on the automated solid-phase synthesis of trizaolo-peptidomimetics.
Hearty welcome and a good start Barbara!

The whole working group met in person (outdoors) for the first time since the start of the Covid-19 pandemic.
It was really nice to meet again and it resulted in a new group picture 🙂 .

The paper of Nathalie Grob (ETH Zurich, CH) entitled Improved Tumor-Targeting with Peptidomimetic Analogs of Minigastrin 177Lu-PP-F11N got published in Cancers.
Congrats Nathalie!

Today, Julia Kronberger starts her PhD on the FWF project Impact of the K-Ras Status on the Activity of Albumin-Targeted Anticancer Drugs (project No. P32886-B).
This is a collaboration with Prof. P. Heffeter (Medical University of Vienna) and Prof. C. Kowol (University of Vienna).
Hearty welcome and a good start Julia!

Our publication on 1,5-Disubstituted 1,2,3-Triazoles as Amide Bond Isosteres Yield Novel Tumor-Targeting Minigastrin Analogs just came out in Medicinal Chemistry Letters.
This work is the results of a collaboration with my former postdoc Dr. Ibai Valverde (Université de Bourgogne, FR) and former PhD student Dr. Nathalie Grob (ETH Zurich, CH).

Today we welcome two new group members: Dr. Veronika Felber and Anna Stingeder.
Vroni will work on an LBIAD project that aims at novel imaging applications and Anna will support our group in any regards to biological experiments.
Hearty welcome and a good start Anna and Vroni!

Today is the last day of Dr. Lisa Recnik who worked on an FWF project investigating peptidomimetics for applications in nuclear medicine (project No. P 31477-B28).
All the best and good luck for the future Lisa!

Read up on the updated regulations for the production of radiopharmaceuticals:
Guideline Guideline on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals published in the European Journal of Nuclear Medicine and Molecular Imaging – Radiopharmacy and Chemistry.
This guideline is the result of Tom´s involvement in the Radiopharmacy committee of the EANM.

Today starts Dr. Barbara Lugato on an industry project developing new applications for Auger electron emitting radionuclides in collaboration with French academic and industrial partners.
Hearty welcome and a good start Barbara!

Today starts Dr. Volkan Tekin on an industry project for the development novel chelators for therapeutic radiometals in collaboration with Prof. G. Gasser of the Chimie ParisTech. Hearty welcome and a good start Volkan!

Today starts Dr. Irene Feiner on the FFG Bridge-1 project Radiostar (project No. 880630) which is a collaboration with colleagues of the Technical University of Vienna and the Austrian company DSD-Pharma.
Hearty welcome and a good start Irene!

In the midst of the Covid-19 pandemic, Tom Mindt becomes Professor in Bioinorganic Radiochemistry at the University of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry.